The Role of Wnt/b-Catenin Signaling and K-Cadherin in the Regulation of Intraocular Pressure
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چکیده
Citation: Webber HC, Bermudez JY, Millar JC, Mao W, Clark AF. The role of Wnt/b-catenin signaling and K-cadherin in the regulation of intraocular pressure. Invest Ophthalmol Vis Sci. 2018;59:1454–1466. https://doi.org/ 10.1167/iovs.17-21964 PURPOSE. Wnt/b-catenin signaling in the trabecular meshwork (TM) is required for maintaining normal intraocular pressure (IOP), although the mechanism(s) behind this are unknown. We hypothesize that Wnt/b-catenin signaling regulates IOP via b-catenin’s effects on cadherin junctions.
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متن کاملThe Role of Wnt/β-Catenin Signaling and K-Cadherin in the Regulation of Intraocular Pressure
Purpose Wnt/β-catenin signaling in the trabecular meshwork (TM) is required for maintaining normal intraocular pressure (IOP), although the mechanism(s) behind this are unknown. We hypothesize that Wnt/β-catenin signaling regulates IOP via β-catenin's effects on cadherin junctions. Methods Nonglaucomatous primary human TM (NTM) cells were treated with or without 100 ng/ml Wnt3a, 1 μg/ml sFRP1...
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